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Normally, after activation through T-cell receptor, calcineurin dephosphorylates a ‘nuclear factorof activated T-cells’ (NFAT) which translocates to the nucleus and triggers transcription of cytokine genes resulting inproduction of IL-2 and other cytokines

Normally, after activation through T-cell receptor, calcineurin dephosphorylates a ‘nuclear factorof activated T-cells’ (NFAT) which translocates to the nucleus and triggers transcription of cytokine genes resulting inproduction of IL-2 and other cytokines.

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